Two-component Signal Transduction as Attractive Drug Targets in Pathogenic Bacteria

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview

The bacterial communities in a wide range of environmental niches sense and respond to numerous external stimuli for their survival. Primarily, a source they require to follow up this communication is the two-component signal transduction system (TCS), which typically comprises a sensor Histidine kinase for receiving external input signals and a response regulator that conveys a proper change i...

Two-component signal transduction proteins as potential drug targets in medically important fungi.

Two-component signal transduction systems in oral bacteria

We present an overview of how members of the oral microbiota respond to their environment by regulating gene expression through two-component signal transduction systems (TCSs) to support conditions compatible with homeostasis in oral biofilms or drive the equilibrium toward dysbiosis in response to environmental changes. Using studies on the sub-gingival Gram-negative anaerobe Porphyromonas gi...

Two-component signal transduction.

Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein. The histidine protein kinase, which is regulated by environmental stimuli, autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to an ...

Two-component signal transduction in Enterococcus faecalis.

Enterococci are gram-positive constituents of the normal human microflora, typically colonizing the intestinal tract and skin (34, 47). However, these organisms are capable of causing disease as opportunistic pathogens, mainly in immunocompromised patients (35, 58). The problem of enterococcal infection has been aggravated by the emergence in the past decade of multiple antibiotic resistance, w...